WASHINGTON — The House of Representatives on Tuesday ousted the Republican Kevin McCarthy as speaker, the first time in history that the chamber has dethroned its leader in a no-confidence vote.

McCarthy was voted out as speaker when a small band of eight hardline conservative Republicans joined all Democrats to approve a “motion to vacate” introduced by Florida GOP Rep. Matt Gaetz, a longtime foe of McCarthy’s.

Moments after the vote ended, a close McCarthy ally, GOP Rep. Patrick McHenry of North Carolina assumed the role of Speaker Pro Tem.

McCarthy’s ouster was effectively set in quick motion on Saturday when he pulled off a surprising legislative victory, getting Democrats to join Republicans in approving a short-term funding bill that avoided a government shutdown.

While McCarthy pleased the White House with that move, it fueled already simmering resentments over his leadership among far-right members of the GOP caucus.

Several of McCarthy’s supporters have said they plan to offer his name for the next round of speaker votes.

But other members of GOP leadership have also been floated as potential replacements, including Majority Whip Tom Emmer of Minnesota and Majority Leader Steve Scalise of Louisiana. Both of them are popular  among the rank-and-file Republicans.

The last time a motion to vacate vote on the House floor occurred was in 1910, when then-Republican Speaker Joseph Cannon survived it.

McCarthy’s hold on the speakership had been tenuous since he was elected in January, due to a small clique led by Gaetz who are unhappy with the Californian.

One source told NBC News on Tuesday that some McCarthy allies were “begging” a number of Democratic House members to vote with them to save his speakership.

“We need Kevin McCarthy to remain as our speaker,” said Majority Whip Tom Emmer, R-Ind., during the debate. “We’re going to stay focused on our mission of delivering common sense wins for the American people.”

Gaetz said, “The one thing that the White House, Democrats and many of us on the conservative side of the Republican caucus have in common is McCarthy said something to all of us at one point that he didn’t really mean and never intended to live up to.”

“There’s nothing selfish about wanting a speaker of the House who tells the truth,” he said.

Gaetz claims that McCarthy no longer represents the interests of the GOP caucus after the speaker worked with Democrats to pass a stopgap funding bill to avoid a government shutdown over the weekend.

“Look, I’m an optimist because I think there’s no point in being anything else,” McCarthy said on his way to the House floor before his backers lost a motion seeking to delay debate on Gaetz’s motion to vacate.

House Minority Leader Hakeem Jeffries, D-N.Y., in a statement said he and other Democratic leaders in the chamber “will vote yes” on Gaetz’s motion to oust McCarthy.

“It is now the responsibility of the GOP members to end the House Republican Civil War,” Jeffries said.

Gaetz has been threatening McCarthy with a motion to vacate since he worked with Democrats on a debt ceiling deal in the spring.

McCarthy told CNBC’s “Squawk Box” on Tuesday morning that Gaetz has “personal things in his life that he has challenges with.”

In January, as a condition to secure enough votes to become speaker, McCarthy agreed to change the rules to lower the threshold needed to bring a motion to oust a speaker from five votes to just one.